Laboratório de Investigação Pulmonar

Publicações

R.F. Magalhães, D.G. Cruz, M.A. Antunes, M.V.S. Fernandes, M.V. Oliveira, C.L. Braga, J. Satalin, P. Andrews, N. Habashi, G. Nieman, C.F.G. de-Albuquerque, A.R. Silva, R.V. Ribeiro, V.L. Capelozzi, F.F. Cruz, C.S. Samary, P.R.M Rocco, P.L. Silva. Time-controlled adaptive ventilation versus volume-controlled ventilation in experimental pneumonia. Critical Care Medicine. 49(1):140-150, 2021. / Pubmed
C. Robba, D. Battaglini, L. Ball, A. Valbusa, I. Porto, R. Bona, G. Malfa, N. Patroniti, I. Brunetti, M. Loconte, M. Bassetti, D.R. Giacobbe, A. Vena, C.L.M. Silva, P.R.M. Rocco, P. Pelosi. Coagulative disorders in critically Ill COVID-19 patients with Acute Distress Respiratory Syndrome: A critical review. Journal of Clinical Medicine. 10(1):140, 2021. / Pubmed
M. Scharffenberg, L. Moraes, A. Güldner, R. Huhle, A. Braune, I. Zeidler-Rentzsch, M. Kasper, C. Kunert-Keil, T. Koch, P. Pelosi, P.R.M. Rocco, M.G. de Abreu, T. Kissy. Comparative effects of neurally adjusted ventilatory assist and variable pressure support on lung and diaphragmatic function in a model of acute respiratory distress syndrome: An experimental randomised study. European Journal of Anaesthesiology. 37:1-10, 2021. / Pubmed
H. Amatullah, T. Maron-Gutierrez, Y. Shan, S. Gupta, J.N. Tsoporis, A.K. Varkouhi, A.P.T. Monteiro, X. He, J. Yin, J.C. Marshall, P.R.M. Rocco, H. Zhang, W.M. Kuebler, C.C. Santos. Protective function of DJ-1/PARK7 in Lipopolysaccharide and Ventilator-Induced Acute Lung Injury. Redox Biology. 38:101796, 2021. / Pubmed
M.L. Pacheco, P.L. Silva, F.F. Cruz, D. Battaglini, C. Robba, P. Pelosi, M.M. Morales, C.C. Neves, P.R.M. Rocco. Pathogenesis of multiple organ injury in COVID-19 and potential therapeutic approaches. Frontiers in Physiology. 12:593223, 2021. / Pubmed
S.C. Abreu, M.L. Pacheco, D.J. Weiss, P.R.M. Rocco. Mesenchymal stromal cell-derived extracellular vesicles in lung diseases: current status and perspectives. Frontiers in Cell and Developmental Biology. 9:600711. 2021. / Pubmed
L. Ball, C. Robba, L. Maiello, J. Herrmann, S.E. Gerard, Yi Xin, D. Battaglini, I. Brunetti, G. Minetti, S. Seitun, A. Vena, D.R. Giacobbe, M. Bassetti, P.R.M. Rocco, M. Cereda, L. Castellan, N. Patroniti, P. Pelosi. Computed tomography assessment of PEEP-induced alveolar recruitment in patients with severe COVID-19 pneumonia. Critical Care. 2021.
D. Battaglini, P.R.M. Rocco, C. Robba, L. Ball, P. Pelosi. Ten golden rules to individualize mechanical ventilation in acute respiratory distress syndrome. Journal of Intensive Medicine. 1(1):42-51, 2021.
D.G. Cruz, R.F. Magalhães, G.A. Padilha, M.C. Silva, C.L. Braga, A.R. Silva, C.F.G. Albuquerque, V.L. Capelozzi, C.S. Samary, P. Pelosi, P.R.M. Rocco, P.L. Silva. Impact of positive biphasic pressure during low and high inspiratory efforts in pseudomonas aeruginosa-induced pneumonia. Plos One. 16(2):e0246891, 2021. / Pubmed
M. Scharffenberg, L. Moraes, A. Güldner, R. Huhle, A. Braune, I. Zeidler-Rentzsch, M. Kasper, C. Kunert-Keil, T. Koch, P. Pelosi, P.R.M. Rocco, M.G. de Abreu, T. Kissy. Comparative effects of neurally adjusted ventilatory assist and variable pressure support on lung and diaphragmatic function in a model of acute respiratory distress syndrome: An experimental randomised study. European Journal of Anaesthesiology. 38(1):32-40, 2021. / Pubmed
P.R.M. Rocco, P.L. Silva, F.F. Cruz, M.A.C.M. Junior, P.F.G.M.M. Tierno, M.A. Moura, L.F.G. Oliveira, C.C. Lima, E.A. Santos, W.F. Junior, A.P.S.M. Fernandes, K.G. Franchini, E. Magri, N.F. Moraes, J.M.J. Gonçalves, M.N. Carbonieri, I.S. Santos, N.F. Paes, P.V.M. Maciel, R.P. Rocha, A.F. Carvalho, P.A. Alves, J.L.P. Modena, A.T. Cordeiro, D.B.B. Trivella, R.E. Marques, R.R. Luiz, P. Pelosi, J.R.L. Silva, SARITA-2 investigators. Early use of nitazoxanide in mild Covid-19 disease: randomised, placebo-controlled trial. European Respiratory Journal. 2003725, 2021. / Pubmed
D. Battaglini, D. Siwicka-Gieroba, P.R.M. Rocco, F.F. Cruz, P.L. Silva, W. Dabrowski, I. Brunetti, N. Patroniti, P. Pelosi, C. Robba. Novel synthetic and natural therapies for traumatic brain injury. Current Neuropharmacology. 19(10):1661-1687, 2021. / Pubmed
L. Ball, C. Robba, L. Maiello, J. Herrmann, S.E. Gerard, Yi Xin, D. Battaglini, I. Brunetti, G. Minetti, S. Seitun, A. Vena, D.R. Giacobbe, M. Bassetti, P.R.M. Rocco, M. Cereda, L. Castellan, N. Patroniti, P. Pelosi. Computed tomography assessment of PEEP-induced alveolar recruitment in patients with severe COVID-19 pneumonia. Critical Care. 25(1):81, 2021. / Pubmed
C. Robba, D. Battaglini, L. Ball, P. Pelosi, P.R.M. Rocco. Ten things you need to know about intensive care unit management of mechanically ventilated patients with COVID-19. Expert Review of Respiratory Medicine. 15(10):1293-1302, 2021. / Pubmed
S.R. Enes, T.H. Hampton, J. Barua, D.H. McKenna, C.C. Santos, E. Amiel, A. Ashare, K.D. Liu, A.D. Krasnodembskaya, K. English, B.A. Stanton, P.R.M. Rocco, M.A. Matthay, D.J. Weiss. Healthy versus inflamed lung environments differentially effect MSCs. European Respiratory Journal. 2004149, 2021. / Pubmed
C. Robba, L. Ball, D. Battaglini, D. Cardim, E. Moncalvo, I. Brunetti, M. Bassetti, D.R. Giacobbe, A. Vena, N. Patroniti, P.R.M. Rocco, B.F. Matta, P. Pelosi. Early effects of ventilatory rescue therapies on systemic and cerebral oxygenation in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: a prospective observational study. Critical Care. 25 (1): 111, 2021. / Pubmed
F.F. Cruz, P.R.M. Rocco, P. Pelosi. Immunomodulators in anesthesia. Current Opinion in Anesthesiology. 34(3):357-363, 2021. / Pubmed
M.A. Antunes, M. Lopes-Pacheco, P.R.M. Rocco. Oxidative stress-derived mitochondrial dysfunction in chronic obstructive pulmonary disease: a concise review. Oxidative Medicine and Cellular Longevity. 2021.
L.R.P. Carvalho, S.C. Abreu, L.L. Castro, L.H.A. Silva, P. Mattos-Silva, J.B. Vieira, R.T. Santos, M.R. Cabral, M. Khoury, D.J. Weiss, M. Lopes-Pacheco, P.L. Silva, F.F. Cruz, P.R.M. Rocco. Mitochondria-rich fraction isolated from mesenchymal stromal cells reduces lung and distal organ injury in experimental sepsis. Critical Care Medicine. 49(9): e880-e890, 2021. Impact factor: 7.414. doi: 10.1097/CCM.0000000000005056. / Pubmed
C. Robba, A. Messina, D. Battaglini, L. Ball, I. Brunetti, M. Bassetti, D. R. Giacobbe, A. Vena, N. Patroniti, M. Cecconi, B.F. Matta, X. Liu, P.R.M. Rocco, M. Czosnyka, P. Pelosi. Effects of passive leg raising test, fluid challenge and norepinephrine on cerebral autoregulation in COVID-19 critically ill patients. Frontiers in Neurology. 2021.
M.A. Antunes, C.L. Braga, T.B. Oliveira, J.Z. Kitoko, L.L. Castro, D.G. Xisto, M.S. Coelho, N.N. Rocha, E.G. Martins, A. Galina, D.J. Weiss, J.R.L. Silva, M. Lopes-Pacheco, F.F. Cruz, P.R.M. Rocco. Mesenchymal stromal cells from emphysematous donors and their extracellular vesicles are unable to reverse cardiorespiratory dysfunction in experimental severe emphysema. Frontiers in Cell and Developmental Biology. 2021.
D. Battaglini, C. Robba, A. Fedele, S. Tranca, S.G. Sukkar, M. Bassetti, D.R. Giacobbe, A. Vena, N. Patroniti, L. Ball, I. Brunetti, A.T. Martí, P.R.M. Rocco, P. Pelosi. The role of dysbiosis in critically ill patients with COVID-19 and Acute Respiratory Distress Syndrome. Frontiers in Medicine. 2021.
L. Ball, C. Robba, J. Herrmann, S. Gerard, Y. Xin, M. Mandelli, D. Battaglini, I. Brunetti, G. Minetti, S. Seitun, G. Bovio, A. Vena, D. Giacobbe, M. Basseti, P.R.M. Rocco, M. Cereda, R. Rizi, L. Castellan, N. Patroniti, P. Pelosi. Lung distribution of gas and blood volume in critically ill COVID-19 patients: a quantitative dual-energy computed tomography study. Critical Care. 25(1): 214, 2021. / Pubmed
D. Battaglini, C. Robba, L. Ball, P.L. Silva, F. Cruz, P. Pelosi, P.R.M. Rocco. Non-invasive respiratory support and patient self-inflicted lung injury in COVID-19: a narrative review. British Journal of Anaesthesia. 127(3):353-364, 2021. / Pubmed
D. Battaglini, F. Missale, I. Schiavetti, M. Filauro, F. Iannuzzi, A. Ascoli, A. Bertazzoli, F. Pascucci, S. Grasso, F. Murgolo, S. Binda, D. Maraggia, G. Montrucchio, G. Sales, G. Pascarella, F.E. Agrò, G. Faccio, S. Ferraris, S. Spadaro, G. Falò, N. Mereto, A. Uva, J.G. Maugeri, B. Agrippino, M. Vargas, G. Servillo, C. Robba, L. Ball, F. Mora, A. Signori, A. Torres, D.R. Giacobbe, A. Vena, M. Bassetti, G. Peretti, P.R.M. Rocco, P. Pelosi. Tracheostomy timing and outcome in severe COVID-19: the WeanTrach multicenter study. Journal of Clinical Medicine. 10(12): 2651, 2021. / Pubmed
M.C. Barbosa-Silva, M.N. Lima, D. Battaglini, C. Robba, P. Pelosi, P.R.M. Rocco, T. Maron-Gutierrez. Infectious Disease-Associated Encephalopathies. Critical Care. 25 (1): 236, 2021. / Pubmed
C.M. Nogueira, C.M. Silva, F.D. Ornellas, D.D. Ornellas, P.R.M. Rocco, C.L. Santos, C. Takiya, F.F. Cruz, M.M. Morales. Therapeutic potential of extracellular vesicles secreted by adipose tissue-derived mesenchymal stromal cells in acute kidney injury induced by sepsis. Cytotherapy. 23(5): S114. 2021.
L.R.P. Carvalho, S.C. Abreu, L.L. Castro, L.H.A. Silva, P. Mattos-Silva, J.B. Vieira, R.T. Santos, M.R. Cabral, M. Khoury, D.J. Weiss, M. Lopes-Pacheco, P.L. Silva, F.F. Cruz, P.R.M. Rocco. Mitochondria isolated from mesenchymal stromal cells reduce lung and distal organ injury in experimental sepsis. Cytotherapy. 23(5): S46. 2021.
M. Barbosa-Silva, M. Lima, E. Amorim, A. Silva, R. Freitas, B. Passos, H. Oliveira, R. Campos, C. Moraes, M. Granja, V. Estato, P.R.M. Rocco, H. Faria-Neto, T. Maron-Gutierrez. Mesenchymal stromal cells protect the blood-brain barrier and prevent cognitive and behavioral impairments in infectious disease-associated encephalopathies. Cytotherapy. 23(5):S39. 2021.
P. Pelosi, L. Ball, C.S.V. Barbas, R. Bellomo, K.E.A. Burns, S. Einav, L. Gattinoni, J.G. Laffey, J.J. Marini, S.N. Myatra, M.J. Schultz, J.L. Teboul, P.R.M. Rocco. Personalized mechanical ventilation in Acute Respiratory Distress Syndrome. Critical Care. 25(1): 250, 2021. / Pubmed
N.N. Rocha, C.S. Samary, M.A. Antunes, M.V. Oliveira, M.R. Hemerly, P.S. Santos, V.L. Capelozzi, F.F. Cruz, J.J. Marini, P.L. Silva, P. Pelosi, P.R.M. Rocco. The impact of fluid status and decremental PEEP strategy on cardiac function and lung and kidney damage in mild-moderate experimental acute respiratory distress syndrome. Respiratory Research. 2021 (in press).
K.N. Silva, A.L. Nunes Gobatto, Z.S.M. Costa-Ferro, B.R.R. Cavalcante, A.C.I. Caria, L.S.A. França, C.K.V. Nonaka, F.M. Lima, M. Lopes-Pacheco, P.R.M. Rocco, B.S.F. Souza. Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19? Stem Cell Research and Therapy. 12(1): 425, 2021. / Pubmed
N.N. Rocha, C.S. Samary, M.A. Antunes, M.V. Oliveira, M.R. Hemerly, P.S. Santos, V.L. Capelozzi, F.F. Cruz, J.J. Marini, P.L. Silva, P. Pelosi, P.R.M. Rocco. The impact of fluid status and decremental PEEP strategy on cardiac function and lung and kidney damage in mild-moderate experimental acute respiratory distress syndrome. Respiratory Research. 22: 214, 2021. / Pubmed
T.S. Oliveira, A.T. Santos, C.B.V. Andrade, J.D. Silva, N.G. Blanco, P.L. Silva, P.R.M. Rocco, W.S. Silva, T.M. Ortiga-Carvalho, F.F. Bloise. Sepsis disrupts mitochondrial function and diaphragm morphology. Frontiers in Physiology. 2021 (in press).
J. Wittenstein, M. Scharffenberg, Xi Ran, Y. Zhang, D. Keller, S. Tauer, R. Theilen, Y. Chai, J. Ferreira, S. Müller, T. Bluth, T. Kiss, M.J. Schultz, .R.M. Rocco, P. Pelosi, M.G. Abreu, R. Huhle. Effects of body position and hypovolemia on the regional distribution of pulmonary perfusion during one-lung ventilation in pigs. Frontiers in Physiology. 2021 (in press).
A.F. Thompson, L. Moraes, N.N. Rocha, M.V.S. Fernandes, M.A. Antunes, S.C. Abreu, C.L. Santos, V.L. Capelozzi, C.S. Samary, M.G. Abreu, F. Saddy, P. Pelosi, P.L. Silva, P.R.M. Rocco. Impact of different frequencies of controlled breath and pressure-support levels during biphasic positive airway pressure ventilation on the lung and diaphragm in experimental mild acute respiratory distress syndrome. PLoS One. 16(8):e0256021, 2021. / Pubmed
C. Robba, L. Ball, S. Nogas, D. Battaglini, A. Messina, I. Brunetti, G. Minetti, L. Castellan, P.R.M. Rocco, P. Pelosi. Effects of positive end-expiratory pressure on lung recruitment, respiratory mechanics and intracranial pressure in mechanically ventilated brain injured patients. Frontiers in Physiology. 2021 (in press).
L. Ball, Y. Sutherasan, M. Fiorito, A. Dall'Orto, L. Maiello, M. Vargas, C. Robba, I. Brunetti, D. D’Antini, P. Raimondo, R. Huhle, M.J. Schultz, P.R.M. Rocco, M.G. Abreu, P. Pelosi. Effects of different levels of variability and pressure support ventilation on lung function in mild-moderate ARDS patients. Frontiers in Physiology. 2021 (in press).
L.B.B. Heil, P.R.M. Rocco. Effects of propofol and its formulation components on macrophages and neutrophils in obese and lean animals. Pharmacology Research & Perspectives. 2021 (in press).
M. Scharffenberg, J. Wittenstein, Xi Ran, Y. Zhang, A. Braune, R. Theilen, L. Maiello, G. Benzi, T. Bluth, T. Kiss, P. Pelosi, P.R.M. Rocco, M.J. Schultz, J. Kotzerke, M.G. Abreu, R. Huhle. Mechanical power correlates with lung inflammation assessed by positron-emission tomography in experimental acute lung injury in pigs. Frontiers in Physiology. 2021 (in press).
L.B. Heil, F.F. Cruz, M.A. Antunes, C.L. Braga, L.C. Agra, R. Bose, S.C. Abreu, P. Pelosi, P.L. Silva, P.R.M. Rocco. Effects of propofol and its formulation components on macrophages and neutrophils in obese and lean animals. Pharmacology Research and Perspectives. 9(5): e00873. 2021 (in press).
J. Wittenstein, R. Huhle, M. Leiderman, M. Möbius, A. Braune, S. Tauer, P. Herzog, G. Barana, A. Ferrari, A. Corona, T. Bluth, T. Kiss, A. Güldner, M.J. Schultz, P.R.M. Rocco, P. Pelosi, M.G. Abreu, M. Scharffenberg. Effect of patient-ventilator asynchrony on lung and diaphragmatic injury in experimental acute respiratory distress syndrome in a porcine model. British Journal of Anaesthesia. S0007-0912(21)00717-0. 2021 (in press). / Pubmed
D.A.F. Caldeira, D.J. Weiss, P.R.M. Rocco, P.L. Silva, F.F. Cruz. Mitochondria in focus: from function to therapeutic strategies in chronic lung diseases. Frontiers in Immunology. 12:782074. 2021 (in press). / Pubmed
C.H. Masterson, A. Ceccato, A. Artigas, C. dos Santos, P.R.M. Rocco, S. Enes, D.J. Weiss, D. McAuley, M.A. Matthay, K. English, G.F. Curley, J.G. Laffey. Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges. Intensive Care Medicine Experimental. 2021 (in press).
G.C. Sousa, M.V.S. Fernandes, F.F. Cruz, M.A. Antunes, C.M. Silva, C. Takyia, D. Battaglini, C.S. Samary, C. Robba, P. Pelosi, P.R.M. Rocco, P.L. Silva. Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke. Scientific Reports. 11(1): 23133. 2021 (in press).
C.H. Masterson, A. Ceccato, A. Artigas, C. Santos, P.R.M. Rocco, S.R. Enes, D.J. Weiss, D. McAuley, M.A. Matthay, K. English, G.F. Curley, J.G. Laffey. Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges. Intensive Care Medicine Experimental. 9(1): 61, 2021.